We tackle the recently released Amiodarone, Lidocaine, or Placebo study. The study attempts to answer the question of which medication, if any, is better in out-of-hospital cardiac arrest with shock refractory VF or VT. Amiodarone and Lidocaine have been a core tenant of ACLS for quite some time. But do they actually work?
Well, the evidence seems to say no.
Overall, neither amiodarone nor lidocaine resulted in a significantly higher rate of survival or favorable neurologic outcome than the rate with placebo among patients with out-of-hospital cardiac arrest due to initial shock-refractory ventricular fibrillation or pulseless ventricular tachycardia.
Does this mean we should start looking at our cardiac arrests a little differently?
- Featured image copyright of Dom Pates (Flickr)
- Kudenchuk, P. J., Brown, S. P., Daya, M., …., (2016). Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest. The New England journal of medicine.
- Antiarrhythmic drugs found beneficial when used by EMS treating cardiac arrest. National Heart, Lung, and Blood Institute, Retrieved from web 4/4/2016.
- Hagihara, A., Hasegawa, M., Abe, T., Nagata, T., Wakata, Y., & Miyazaki, S. (2012). Prehospital epinephrine use and survival among patients with out-of-hospital cardiac arrest. JAMA, 11, 1161–1168.
- PARAMEDIC2 Trial