Critical Care Paramedicine Podcast

Episode 8: Conquering the ALPS (Study)

We tackle the recently released Amiodarone, Lidocaine, or Placebo study. The study attempts to answer the question of which medication, if any, is better in out-of-hospital cardiac arrest with shock refractory VF or VT. Amiodarone and Lidocaine have been a core tenant of ACLS for quite some time. But do they actually work?

Well, the evidence seems to say no.

Overall, neither amiodarone nor lidocaine resulted in a significantly higher rate of survival or favorable neurologic outcome than the rate with placebo among patients with out-of-hospital cardiac arrest due to initial shock-refractory ventricular fibrillation or pulseless ventricular tachycardia.

The details of the data are somewhat interesting. When you break down the data to various subgroups, you actually see where the Amiodarone and Lidocaine actually fair somewhat well.

Does this mean we should start looking at our cardiac arrests a little differently?

Show Notes


  1. […] is not one of the researchers, so that is easy to overlook. The rest of the podcast is excellent. Listen to it here. […]

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